Assoc Director/Director, DMPK

DMPK (400) · Seattle, Washington
Department DMPK (400)
Employment Type Full-Time
Minimum Experience Mid-level

Associate Director/ Director, DMPK


At Chinook

Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for kidney diseases. Chinook’s product candidates are being investigated in rare, severe chronic kidney disorders with opportunities for well-defined clinical pathways. Chinook’s lead program is atrasentan, a phase 3 endothelin receptor antagonist for the treatment of IgA nephropathy and other proteinuric glomerular diseases. BION-1301, an anti-APRIL monoclonal antibody is being evaluated in a phase 1b trial for IgA nephropathy. In addition, Chinook is advancing CHK-336, an oral small molecule LDHA inhibitor for the treatment of primary hyperoxaluria, as well as research programs for other rare, severe chronic kidney diseases.

 

Chinook is building its pipeline by leveraging insights in kidney single cell RNA sequencing, human-derived organoids, and new translational models, to discover and develop therapeutics with differentiating mechanisms of action against key kidney disease pathways. Chinook trades on Nasdaq under the ticker symbol KDNY and has locations in Vancouver, BC, Seattle, WA and Oakland, CA.


The Opportunity

The Company is seeking to hire an Associate Director/ Director, DMPK with expertise in drug discovery and early development.  The incumbent will lead the DMPK team at our laboratories situated in Vancouver as well as lead IND-enabling activities as a key member of the early translational team. The successful incumbent will be responsible for mentoring DMPK staff and ensuring execution of strategies necessary to address key DMPK issues for multiple programs across Chinook’s discovery pipeline.

 

The successful candidate will work with the DMPK team to drive DMPK strategy on early programs across all stages of research and development.  As a key member of the translational team, the candidate will provide fit-for-purpose PK/PD analysis and translation of human PK and dose predictions, as well as drug-drug interaction risk assessment.  The ideal candidate will possess strong leadership and communication skills, will be able to lead projects independently, develop junior staff, and will propose innovative solutions to DMPK issues. Candidates will work within multidisciplinary drug discovery and clinical development teams.

 

Responsibilities Include:

  • Supervise and mentor members of the DMPK team
  • Manage/ provide oversight of the DMPK team to prioritize internal and external DMPK studies to support research and development pipeline
  • Design and oversee conduct of DMPK studies that support clinical trials and product registration
  • Key contributor to DMPK strategy by acting on interdisciplinary research and development project teams
  • Identify and employ new technologies/platforms that address current and future challenges (e.g. In Silico, PBPK)
  • Author or provide oversight for preparations of Nonclinical Pharmacokinetics and Metabolism portions of regulatory (e.g. CTA, IND, NDA) and clinical documents (IB).
  • Serve as a subject matter expert in composing responses to regulatory queries
  • Author and provide oversight for preparations of DMPK portions of regulatory submissions (CTA, IND, NDA) and clinical documents (IB)

 

Education, Experience and Skills:

  • Ph.D. with a minimum of 8 years or M.Sc. with 12+ years of biotech/pharmaceutical drug discovery and development experience as a subject matter expert in drug metabolism, pharmacokinetics or a related discipline.
  • Excellent critical thinking and scientific skills with expertise in small molecule metabolism and pharmacokinetics. Large molecule experience will be an asset.
  • Demonstrated ability to work effectively and collaboratively on cross functional project teams in discovery and development.
  • Ability to lead a DMPK team, represent the DMPK and program strategy at scientific and executive meeting and positively influence and grow colleagues.
  • Excellent oral presentation and written communication skills.

 

Chinook is an Equal Opportunity Employer, and we prohibit discrimination or harassment of any kind.  We are committed to fostering an environment where ALL people are welcome and supported.  We respect and value different experiences and viewpoints.  We act respectfully toward one another and embrace diversity of people and ideas. Having a diverse workforce made up of team members who bring a wide variety of skills, abilities, experiences, and perspectives is essential to our success. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect.

 

Thank You

Your application was submitted successfully.

  • Location
    Seattle, Washington
  • Department
    DMPK (400)
  • Employment Type
    Full-Time
  • Minimum Experience
    Mid-level