Associate Director/ Director, DMPK
Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for kidney diseases. Chinook’s product candidates are being investigated in rare, severe chronic kidney disorders with opportunities for well-defined clinical pathways. Chinook’s lead program is atrasentan, a phase 3 endothelin receptor antagonist for the treatment of IgA nephropathy and other proteinuric glomerular diseases. BION-1301, an anti-APRIL monoclonal antibody is being evaluated in a phase 1b trial for IgA nephropathy. In addition, Chinook is advancing CHK-336, an oral small molecule LDHA inhibitor for the treatment of primary hyperoxaluria, as well as research programs for other rare, severe chronic kidney diseases.
Chinook is building its pipeline by leveraging insights in kidney single cell RNA sequencing, human-derived organoids, and new translational models, to discover and develop therapeutics with differentiating mechanisms of action against key kidney disease pathways. Chinook trades on Nasdaq under the ticker symbol KDNY and has locations in Vancouver, BC, Seattle, WA and Oakland, CA.
The Company is seeking to hire an Associate Director/ Director, DMPK with expertise in drug discovery and early development. The incumbent will lead the DMPK team at our laboratories situated in Vancouver as well as lead IND-enabling activities as a key member of the early translational team. The successful incumbent will be responsible for mentoring DMPK staff and ensuring execution of strategies necessary to address key DMPK issues for multiple programs across Chinook’s discovery pipeline.
The successful candidate will work with the DMPK team to drive DMPK strategy on early programs across all stages of research and development. As a key member of the translational team, the candidate will provide fit-for-purpose PK/PD analysis and translation of human PK and dose predictions, as well as drug-drug interaction risk assessment. The ideal candidate will possess strong leadership and communication skills, will be able to lead projects independently, develop junior staff, and will propose innovative solutions to DMPK issues. Candidates will work within multidisciplinary drug discovery and clinical development teams.
Education, Experience and Skills:
Chinook is an Equal Opportunity Employer, and we prohibit discrimination or harassment of any kind. We are committed to fostering an environment where ALL people are welcome and supported. We respect and value different experiences and viewpoints. We act respectfully toward one another and embrace diversity of people and ideas. Having a diverse workforce made up of team members who bring a wide variety of skills, abilities, experiences, and perspectives is essential to our success. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect.
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