Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for kidney diseases. Chinook’s product candidates are being investigated in rare, severe chronic kidney disorders with opportunities for well-defined clinical pathways. Chinook’s lead program is atrasentan, a phase 3 endothelin receptor antagonist for the treatment of IgA nephropathy and other proteinuric glomerular diseases. BION-1301, an anti-APRIL monoclonal antibody is being evaluated in a phase 1/2 trial for IgA nephropathy. In addition, Chinook is advancing CHK-336, an oral small molecule LDHA inhibitor for the treatment of primary hyperoxaluria, as well as research programs for other rare, severe chronic kidney diseases.
Chinook is building its pipeline by leveraging insights in kidney single cell RNA sequencing, human-derived organoids, and new translational models, to discover and develop therapeutics with differentiating mechanisms of action against key kidney disease pathways. Chinook trades on Nasdaq under the ticker symbol KDNY and has locations in Vancouver, BC, Seattle, WA and Oakland, CA.
Chinook Therapeutics is seeking an energetic and collaborative Research Associate or Sr. Research Associate to join the Drug Metabolism and Pharmacokinetics (DMPK) discovery group at our laboratories situated in Vancouver, Canada. The successful candidate will primarily be responsible for developing and implementing LC-MS/MS assays and efficient bio-analytical processes in support of Discovery and Preclinical (non-GLP) studies. This position will also involve detailed troubleshooting of assays to ensure the methods developed are robust and selective for the quantification of analytes of interest, including biomarkers. In this position the individual will plan, execute, and analyze in vitro and in vivo ADME/DMPK studies to support drug discovery and early development.
This individual will have the opportunity to interact and collaborate with members of the chemistry, biology, and pharmacology departments in a dynamic scientific environment, with the goal of developing precision therapies to help patients with kidney diseases.
Education, Experience and Skills:
Chinook is an Equal Opportunity Employer, and we prohibit discrimination or harassment of any kind. We are committed to fostering an environment where ALL people are welcome and supported. We respect and value different experiences and viewpoints. We act respectfully toward one another and embrace diversity of people and ideas. Having a diverse workforce made up of team members who bring a wide variety of skills, abilities, experiences, and perspectives is essential to our success. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect.
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