Research Associate / Sr. Research Associate, Biology

Biology (200) · Vancouver, British Columbia
Department Biology (200)
Employment Type Full-Time
Minimum Experience Mid-level

Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for patients with kidney diseases. We apply our proprietary research platform to discover and develop therapies with novel mechanisms of action in key kidney disease pathways. Our development focus is on rare, serious disorders with clear unmet medical needs and well-defined clinical development opportunities. Our lead program, atrasentan, is a potent and selective, small molecule inhibitor of the endothelin A receptor that is planned to move into a phase 3 registrational trial for IgA nephropathy and a phase 2 basket trial for glomerular diseases, in 2021. We are advancing BION-1301, an anti-APRIL monoclonal antibody, in an ongoing phase 1b trial for IgA nephropathy, and CHK-336, an oral small molecule LDHA inhibitor for primary hyperoxaluria, towards trial initiation in 2021. Our pipeline also includes several additional preclinical programs at the validation and lead optimization stages, and we continue to actively evaluate business development opportunities around early and late-stage clinical assets in kidney disease. 

 

Chinook completed the third quarter of 2020 with over $290 million in operating capital and trades on Nasdaq under the ticker symbol, “KDNY.”  The company has locations in Vancouver, BC, Seattle, WA and Berkeley, CA.


Position:


Chinook Therapeutics is seeking an energetic and collaborative Research Associate or Sr Research Associate to join the Biology discovery team at our laboratories situated in Vancouver, Canada. The successful candidate will be responsible for designing, performing and analyzing in vitro experiments, and contributing to go/no-go decisions in preclinical drug discovery programs. Hands-on experience in cellular biology, molecular biology, and enzymology is required. The ideal candidate will possess strong teamwork and communication skills, will be able to design and perform experiments independently, and will propose innovative solutions to biological questions. Candidates will work within a multidisciplinary drug discovery team of medicinal chemists, DMPK scientists, and in vivo pharmacologists.



Responsibilities include:


  • Design, perform, and analyze in vitro experiments to support the advancement of multiple preclinical drug discovery programs
  • Develop and perform enzyme and cell-based assays to determine potencies and characteristics of novel compounds
  • Establish and execute assays to analyze PD markers in collaboration with a multidisciplinary research team
  • Proactively interrogate research literature and contribute to overall project strategy
  • Participate in and present data in team meetings
  • Mentor co-op students in daily lab activities
  • Contribute to the development and maintenance of a positive team-focused company culture



Education, Experience and Skills:


  • Sc. or M.Sc. degree with at least 5 years of post-graduate research experience
  • Minimum 3 years of industrial experience is required, preferably in a drug discovery setting
  • Hands-on experience in assay development and compound screening
  • Strong working knowledge of cellular biology, molecular biology, and enzymology
  • Effective time management skills and ability to work in a fast-paced team environment, meet deadlines, and prioritize work
  • Ability to analyze, interpret, and present data in clear manner
  • A strong team player with a passion for science and drug discovery
  • Positive attitude and high personal and ethical standards


 


Chinook is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.


 

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  • Location
    Vancouver, British Columbia
  • Department
    Biology (200)
  • Employment Type
    Full-Time
  • Minimum Experience
    Mid-level