Research Associate / Sr. Research Associate, In Vivo Pharmacology

Pharmacology (500) · Vancouver, British Columbia
Department Pharmacology (500)
Employment Type Full-Time
Minimum Experience Experienced

Company:

 

Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for patients with kidney diseases. We apply our proprietary research platform to discover and develop therapies with novel mechanisms of action in key kidney disease pathways. Our development focus is on rare, serious disorders with clear unmet medical needs and well-defined clinical development opportunities. Our lead program, atrasentan, is a potent and selective, small molecule inhibitor of the endothelin A receptor that is planned to move into a phase 3 registrational trial for IgA nephropathy and a phase 2 basket trial for glomerular diseases, in 2021. We are advancing BION-1301, an anti-APRIL monoclonal antibody, in an ongoing phase 1b trial for IgA nephropathy, and CHK-336, an oral small molecule LDHA inhibitor for primary hyperoxaluria, towards trial initiation in 2021. Our pipeline also includes several additional preclinical programs at the validation and lead optimization stages, and we continue to actively evaluate business development opportunities around early and late-stage clinical assets in kidney disease. 

 

Chinook completed the third quarter of 2020 with over $290 million in operating capital and trades on Nasdaq under the ticker symbol, “KDNY.”  The company has locations in Vancouver, BC, Seattle, WA and Berkeley, CA.


Position:


Chinook Therapeutics is seeking an enthusiastic, detail-oriented and collaborative Research Associate or Sr. Research Associate to join the in vivo pharmacology team at our laboratories situated in Vancouver, Canada. The successful candidate will design, plan, execute and analyze in vivo studies for target validation and preclinical research activities. Candidates will rely on their organizational skills and expertise to manage multiple research activities simultaneously and will have the opportunity to interact and collaborate with a multidisciplinary team in a dynamic scientific environment.

 

Responsibilities include: 


  • Conduct in vivo PK/PD studies and drug efficacy studies with disease models to support early drug discovery projects  
  • Organize, execute and maintain multiple in vivo studies running in parallel including data entry and analysis, own responsibility for technical aspects of a project 
  • Perform measurements of in vivo biomarkers of renal disease and dysfunction 
  • Develop and troubleshoot novel in vivo disease models for mechanism of action and biomarker studies 
  • Prepare clear and concise technical reports, study protocols and data presentations 
  • Maintain an accurate lab notebook 
  • Contribute to publications and participate in scientific conferences as applicable 
  • Serve as a technical resource to junior staff/co-op students and leverage expertise in laboratory technology as a functional resource/trainer 
  • Contribute to vivarium maintenance and ordering of supplies

 

Education, Experience and Skills: 


  • B.Sc. or M.Sc. degree with a minimum of 2 years post-graduate research experience and/or in vivo pharmacology experience in pharmaceutical or biotech industry 
  • Hands-on experience performing in vivo studies with rodents, including animal handling, multiple routes of dose administration (IV, PO, SC, IM, etc.), blood collection, dissection techniques, necropsies, evaluation of PD and disease endpoints 
  • Direct experience with animal models of kidney diseases is a plus 
  • Experience in all aspects of working with animal care committees a plus 
  • A strong team player with a passion for scientific excellence and drug discovery  
  • Organized, self-motivated, able to multitask and deliver results with high degree of attention to detail to drive projects forward in a timely manner 
  • Ability to thrive in a fast-pace, multi-disciplinary environment interacting with a diverse group of experts, comfortable with adjusting workloads based upon changing priorities and willing to take on new tasks 
  • Excellent cross-functional interpersonal, verbal and written communication skills. Positive attitude and high personal and ethical standards 
  • Able to work weekends as study schedules dictate

 

Chinook is an Equal Opportunity Employer and we prohibit discrimination or harassment of any kind.  We are committed to fostering an environment where ALL people are welcome and supported.  We respect and value different experiences and viewpoints.  We act respectfully toward one another and embrace diversity of people and ideas. Having a diverse workforce made up of team members who bring a wide variety of skills, abilities, experiences, and perspectives is essential to our success. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect.

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  • Location
    Vancouver, British Columbia
  • Department
    Pharmacology (500)
  • Employment Type
    Full-Time
  • Minimum Experience
    Experienced