Scientist / Sr. Scientist, In Vivo Pharmacology

Pharmacology (500) · Vancouver, British Columbia
Department Pharmacology (500)
Employment Type Full-Time
Minimum Experience Experienced

Company: 

 

Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for patients with kidney diseases.  We apply our proprietary research platform to discover and develop therapeutics with novel mechanisms of action against key kidney disease pathways. Our development focus is on rare, serious disorders with clear unmet medical needs and defined and rapid clinical development opportunities.  Our lead program, atrasentan, is a late-stage clinical program for the treatment of primary glomerular diseases, which is planned to move into a phase 3 registrational trial for IgA nephropathy and a phase 2 basket trial for glomerular diseases, both in early 2021. We are also evaluating BION-1301, an anti-APRIL monoclonal antibody, in a phase 1b trial for IgA nephropathy, and are advancing CHK-336 towards a planned IND in 2021 for an ultra-orphan kidney disease.  In addition, our pipeline has several other preclinical programs at the validation and lead optimization stages, and we are also evaluating business development opportunities for early and late-stage clinical assets to enhance the pipeline. 

 

Chinook launched in 2019 with a $65 million Series A financing from leading healthcare investors Versant Venture, Apple Tree Partners and Samsara Biocapital.  In October 2020, we merged with Aduro Biotech, Inc. and completed a $115 million financing with leading healthcare investors, including EcoR1, Orbimed and others.  Chinook now has over $275 million in operating capital and trades on Nasdaq under the ticker “KDNY”.  The company has locations in Vancouver, BC, Seattle, WA and Berkeley, CA.

 

Position: 

 

Chinook Therapeutics is seeking an enthusiastic and collaborative lab based Scientist / Sr. Scientist to join the in vivo Pharmacology team at our laboratories situated in Vancouver, Canada. The successful candidate will be responsible for leading and supporting aspects of preclinical drug discovery programs, designing and performing experiments to enable go/no-go decisions, and contributing to the overall research strategy at Chinook. Experience working with animal models of renal disease and knowledge of renal physiology/pharmacology are valuable assets. The ideal candidate will possess strong leadership and communication skills, will be able to perform and lead projects independently, and will have the opportunity to collaborate with a multidisciplinary team in a dynamic scientific environment.

 

The Scientist / Sr. Scientist will drive discovery project decisions, take responsibility for an in vivo laboratory team, and apply your knowledge of renal physiology and pharmacology to support mechanistic understanding and their translatability to the human disease.

 

Responsibilities: 

 

  • Interact and collaborate with medicinal chemists, biologists and DMPK scientists to advance preclinical projects by designing and performing in vivo pharmacology studies. 
  • Support drug discovery efforts by providing guidance and expertise in renal biology to identify and establish new in vivo disease models and biomarkers to interrogate mechanisms of action 
  • Work collaboratively with team members to plan and execute multiple in vivo studies; responsibility for leading, supervising, and mentoring direct reports. 
  • Contribute to defining team and department goals; collaborate within and outside of the Chinook to ensure company success 
  • Contribute to publications and participate in scientific conferences as applicable 
  • Contribute to the development and maintenance of a positive team-focused company culture. 

 

Education, Experience and Skills: 

 

  • Ph.D. in physiology, pharmacology or related disciplines and minimum 2 years of progressive in vivo pharmacology industry experience, or equivalent combination of education and experience 
  • A proven track-record project leadership in an academic, pharmaceutical, or biotechnology environment 
  • Extensive hands-on experience designing, performing and interpreting in vivo pharmacokinetic, pharmacodynamic and drug efficacy studies in rodents 
  • Broad knowledge in the areas of renal physiology/pharmacology and small molecule therapeutics 
  • Experience in all aspects in working with animal care committees a plus 
  • A leader and team player with a passion for scientific excellence and drug discovery  
  • Organized, self-motivated, and able to multitask and deliver results with high degree of attention to detail to drive projects forward in a timely manner, comfortable with adjusting workloads based upon changing priorities and willing to take on new tasks 
  • Excellent cross-functional interpersonal, verbal and written communication skills 
  • Positive attitude and high personal and ethical standards 
  • Able to work weekends as study schedules dictate

 

Chinook is an Equal Opportunity Employer and we prohibit discrimination or harassment of any kind.  We are committed to fostering an environment where ALL people are welcome and supported.  We respect and value different experiences and viewpoints.  We act respectfully toward one another and embrace diversity of people and ideas. Having a diverse workforce made up of team members who bring a wide variety of skills, abilities, experiences, and perspectives is essential to our success. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect.

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  • Location
    Vancouver, British Columbia
  • Department
    Pharmacology (500)
  • Employment Type
    Full-Time
  • Minimum Experience
    Experienced