Chinook Therapeutics is a clinical-stage biotechnology company developing precision medicines for patients with kidney diseases. We apply our proprietary research platform to discover and develop therapies with novel mechanisms of action in key kidney disease pathways. Our development focus is on rare, serious disorders with clear unmet medical needs and well-defined clinical development opportunities. Our lead program, atrasentan, is a potent and selective, small molecule inhibitor of the endothelin A receptor that is planned to move into a phase 3 registrational trial for IgA nephropathy and a phase 2 basket trial for glomerular diseases, in 2021. We are advancing BION-1301, an anti-APRIL monoclonal antibody, in an ongoing phase 1b trial for IgA nephropathy, and CHK-336, an oral small molecule LDHA inhibitor for primary hyperoxaluria, towards trial initiation in 2021. Our pipeline also includes several additional preclinical programs at the validation and lead optimization stages, and we continue to actively evaluate business development opportunities around early and late-stage clinical assets in kidney disease.
Chinook completed the third quarter of 2020 with over $290 million in operating capital and trades on Nasdaq under the ticker symbol, “KDNY.” The company has locations in Vancouver, BC, Seattle, WA and Berkeley, CA.
Chinook Therapeutics is seeking a high-performing Sr. Scientist, Translational Medicine to guide biomarker discovery and validation efforts in the Renal Discovery and Translational Medicine group. Reporting to the Director of Translational Medicine, the Sr. Scientist, Translational Medicine will help develop and lead execution of the biomarker strategy to support BION-1301 and other programs ranging from late stage research to Phase 3 clinical studies. The successful candidate will play a key role in developing clinically testable hypotheses and determining approaches to identify predictive and prognostics biomarkers that inform dose selection and patient enrichment/stratification, and interrogate mechanisms of drug action, response and resistance. This will be a visible role working in a matrixed environment across disciplines, including discovery research and clinical development teams, to advance the pipeline of precision medicines for kidney diseases by providing scientific and technical leadership. Our laboratories are based in Vancouver, Canada but the successful candidate could be located in the United States or Canada.
Education, Experience, and Skills:
Chinook is an Equal Opportunity Employer and we prohibit discrimination or harassment of any kind. We are committed to fostering an environment where ALL people are welcome and supported. We respect and value different experiences and viewpoints. We act respectfully toward one another and embrace diversity of people and ideas. Having a diverse workforce made up of team members who bring a wide variety of skills, abilities, experiences, and perspectives is essential to our success. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect.
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